Several problems, such as recognition of surface structures of cell and observation in situ of inner structure of cell, were discussed; what s more, "shape probe" and superthin section were put forward to solve the problems.

對(duì)近年來(lái)原子力顯微技術(shù)(AFM)在細(xì)胞生物學(xué)中的應(yīng)用大致歸納為幾個(gè)方面進(jìn)行了簡(jiǎn)單介紹,還指出了細(xì)胞表面結(jié)構(gòu)難于識(shí)別、細(xì)胞內(nèi)部結(jié)構(gòu)難以原位觀察等AFM應(yīng)用于細(xì)胞生物學(xué)中的難題,并提出了“形狀探針”的概念以及超薄切片的思路以解決這些難題。